What are skin signs of arsenic exposure?

• A. Rashes with blisters
• B. Pale, smooth skin
• C. Dark spots and thickened skin
• D. Hair thinning

Answer: (C)

Chronic arsenic exposure produces a characteristic skin pattern: dark pigmentation patches and thickening of the skin, especially on the palms and soles. This combination—dark spots (hyperpigmentation) with thickened skin (hyperkeratosis)—is the classic skin sign of arsenic toxicity, and it helps distinguish it from other skin conditions. Rashes with blisters are more typical of acute dermatitis or chemical burns and aren’t the hallmark of arsenic exposure. Pale, smooth skin isn’t associated with arsenic, and while arsenic can cause various systemic effects, hair thinning isn’t the defining skin sign here.