Which of the following is a chronic skin sign of arsenic exposure?

• A. Rashes with blisters
• B. Hair curling
• C. Dark spots and thickened skin
• D. Increased warmth of skin

Answer: (C)

Chronic arsenic exposure produces lasting skin changes, with dark spots (hyperpigmentation) and thickened skin (hyperkeratosis) being classic findings, especially on the palms and soles. These telltale changes develop over time as arsenic accumulates in the body and are a hallmark of long-term exposure, and they can be linked to an increased risk of skin cancer. Rashes with blisters point to acute irritation rather than a chronic pattern, hair curling is not a recognized chronic arsenic sign, and increased warmth of the skin isn’t typical of arsenic-related skin effects. Therefore, dark spots and thickened skin best reflect the chronic skin signs of arsenic exposure.